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Rapid adaptive evolution of avian leukosis virus subgroup J in response to biotechnologically induced host resistance

15 Aug 2024

Abstract excerpt

Genetic editing of the germline using CRISPR/Cas9 technology has made it possible to alter livestock traits, including the creation of resistance to viral diseases. However, virus adaptability could present a major obstacle in this effort. Recently, chickens resistant to avian leukosis virus subgroup J (ALV-J) were developed by deleting a single amino acid, W38, within the ALV-J receptor NHE1 using CRISPR/Cas9...

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PMID: 39146367
DOI: 10.1371/journal.ppat.1012468

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