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Article

Precise gene editing of chicken Na+/H+ exchange type 1 (chNHE1) confers resistance to avian leukosis virus subgroup J (ALV-J).

Developmental and comparative immunology - 1 Dec 2017

Lee Hong Jo, Lee Kyung Youn, Jung Kyung Min, Park Kyung Je, Lee Ko On, Suh Jeong-Yong, Yao Yongxiu, Nair Venugopal, Han Jae Yong

Abstract excerpt

Avian leukosis virus subgroup J (ALV-J), first isolated in the late 1980s, has caused economic losses to the poultry industry in many countries. As all chicken lines studied to date are susceptible to ALV infection, there is enormous interest in developing resistant chicken lines. The ALV-J receptor, chicken Na+/H+ exchange 1 (chNHE1) and the critical amino acid sequences involved in viral attachment and entry...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28899753
DOI: 10.1016/j.dci.2017.09.006

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