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Article

Mapping the mutational landscape of an avian retrovirus envelope protein across its evolutionary trajectory.

PLoS pathogens - 1 Mar 2026

Xu Moru, Liu Yupeng, Lan Xin, Wang Zhenyu, Qian Kun, Shao Hongxia, Huang Jinlin, Ye Jianqiang, Qin Aijian

Abstract excerpt

Many RNA viruses exhibit error-prone replication. Continuous generation of erroneous copies accelerates evolution. Avian leukosis virus subgroup J (ALV-J), an avian oncogenic virus, is a classical model virus for studying retroviruses. ALV-J's high mutation rates drive continuous evolution of its envelope and pathogenicity, posing significant challenges to the poultry industry. Here we employed deep mutational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41915665
DOI: 10.1371/journal.ppat.1014110
PMCID: PMC13048475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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