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SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility.

Cell reports - 26 Sept 2023

Kim Se-Mi, Kim Eun-Ha, Casel Mark Anthony B, Kim Young-Il, Sun Rong, Kwak Mi-Jeong, Yoo Ji-Seung, Yu Mina, Yu Kwang-Min, Jang Seung-Gyu, Rollon Rare, Choi Jeong Ho, Gil Juryeon, Eun Kiyoung, Kim Hyunggee, Ensser Armin, Hwang Jungwon, Song Min-Suk, Kim Myung Hee, Jung Jae U, Choi Young Ki

Abstract excerpt

With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to have a comprehensive assessment of their viral fitness and transmissibility. Here, we demonstrate that natural temperature differences between the upper (33°C) and lower (37°C) respiratory tract have profound effects on SARS-CoV-2 replication and transmissibility. Specifically, SARS-CoV-2 variants containing the NSP12...

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Identifiers

PMID: 37676771
DOI: 10.1016/j.celrep.2023.113077
PMCID: PMC11550895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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