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Article

B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy

13 Aug 2024

Abstract excerpt

Key Points Dysregulated IgA production plays a key role in the pathogenesis of IgA nephropathy. Increased 5-methylcytosine modification, an epigenetic regulatory mechanism, exaggerated IgA nephropathy phenotype in mice. Conversely, inhibition of 5-methylcytosine modification ameliorated progression of IgA nephropathy–like kidney disease in mice. Background IgA nephropathy is an important global cause of kidney...

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PMID: 39137052
DOI: 10.1681/asn.0000000000000441

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