Article
MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis.
Journal of the American Society of Nephrology : JASN - 1 Oct 2021
Li Hongzhi, Chen Zhichao, Chen Weitian, Li Jingyi, Liu Yunshuang, Ma Hongchuang, Shi Mingming, Sun Xuelian, Yao Xiusong, Li Zhijun, Pawluczyk Izabella Z A, Zhang Shuchen, Barratt Jonathan, Lv Jicheng, Wang Kai, Zhao Binghai
Abstract excerpt
BACKGROUND: IgA nephropathy (IgAN) is the most common primary GN worldwide. Circulating immune complexes form that are prone to deposition in the mesangium, where they trigger glomerular inflammation. A growing body of evidence suggests that dysregulated expression of microRNAs in IgAN may play a significant role in establishing the disease phenotype. METHODS: We generated single miR-23b-3p(miR-23b) knockout mice...
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