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Article

The effect of depression status on osteoarthritis: A powerful two-step Mendelian randomization study.

Journal of affective disorders - 1 Nov 2024

Yan Zi, Yang Jiaxin, Zhang Huihui, Li Ziyue, Zheng Weihan, Li Shiyu, Huang Wenhua

Abstract excerpt

Osteoarthritis (OA) is a common degenerative disease that affects millions of individuals worldwide. OBJECTIVE: There is no conclusive epidemiological evidence regarding the relationship between OA, depression, and whole-body fat mass. In this study, we conducted a two-step Mendelian randomization analysis to determine the causal relationships between them. DESIGN: The published summary-level data are from...

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PMID: 39134150
DOI: 10.1016/j.jad.2024.08.009

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