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Article

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

3 Oct 2012

Abstract excerpt

Small cell lung cancer (SCLC) accounts for about 15% of all lung cancers. The prognosis of SCLC patients is devastating and no biologically targeted therapeutics are active in this tumor type. To develop a framework for development of specific SCLC-targeted drugs we conducted a combined genomic and pharmacological vulnerability screen in SCLC cell lines. We show that SCLC cell lines capture the genomic landscape...

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PMID: 23035247
DOI: 10.1073/pnas.1207310109

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