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Article

Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation.

PloS one - 1 Jan 2020

Valdez-Lopez Juan C, Gulati Sahil, Ortiz Elelbin A, Palczewski Krzysztof, Robinson Phyllis R

Abstract excerpt

Melanopsin is a visual pigment expressed in a small subset of ganglion cells in the mammalian retina known as intrinsically photosensitive retinal ganglion cells (ipRGCs) and is implicated in regulating non-image forming functions such as circadian photoentrainment and pupil constriction and contrast sensitivity in image formation. Mouse melanopsin's Carboxy-terminus (C-terminus) possesses 38 serine and threonine...

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Identifiers

PMID: 32236094
DOI: 10.1371/journal.pone.0228121
PMCID: PMC7112210

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