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Article

T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8

8 Aug 2024

Abstract excerpt

One of the biggest challenges for in vivo gene therapy are vectors mediating highly selective gene transfer into a defined population of therapy-relevant cells. Here we present DARPin-targeted AAVs (DART-AAVs) displaying DARPins specific for human and murine CD8. Insertion of DARPins into the GH2/GH3 loop of the capsid protein 1 (VP1) of AAV2 and AAV6 resulted in high selectivity for CD8-positive T cells with...

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PMID: 39113357
DOI: 10.1016/j.ymthe.2024.08.002

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