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CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes

12 Mar 2020

Abstract excerpt

Adoptive T cell immunotherapy in combination with gene therapy is a promising treatment concept for chronic infections and cancer. Recently, receptor-targeted lentiviral vectors (LVs) were shown to enable selective gene transfer into particular types of lymphocytes both in vitro and in vivo . This approach might facilitate the genetic engineering of a patient's own T lymphocytes, possibly even shifting this...

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PMID: 32160795
DOI: 10.1089/hum.2019.248

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