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Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth

3 Jul 2024

Abstract excerpt

Bone marrow (BM) is the dominant site of hematopoiesis after 20 post-conception weeks (PCWs), but the intricacies of hematopoietic development in fetal BM up to birth and its involvement in malignancies remain unknown. Here, we compared the single-cell transcriptomic profile of BM hematopoietic stem and progenitor cells (HSPCs) at the early (12-14 PCW), middle (19-22 PCW) second trimester, and the neonatal stage....

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PMID: 39108709
DOI: 10.1016/j.isci.2024.110445

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