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Article

Rational selection of morphological phenotypic traits to extract essential similarities in chemical perturbation in the ergosterol pathway.

Scientific reports - 6 Aug 2024

Ghanegolmohammadi Farzan, Liu Wei, Xu Tingtao, Li Yuze, Ohnuki Shinsuke, Kojima Tetsuya, Itto-Nakama Kaori, Ohya Yoshikazu

Abstract excerpt

Terbinafine, fluconazole, and amorolfine inhibit fungal ergosterol synthesis by acting on their target enzymes at different steps in the synthetic pathway, causing the accumulation of various intermediates. We found that the effects of these three in- hibitors on yeast morphology were different. The number of morphological parameters commonly altered by these drugs was only approximately 6% of the total. Using a...

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Identifiers

PMID: 39107358
DOI: 10.1038/s41598-024-67634-1
PMCID: PMC11303412

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