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Causal relationships of lipid metabolism in diabetic nephropathy risk: A two-sample Mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Apr 2026

Yu Cui, Zhang Houwen, Ni Feizhen, Jin Lu, Ying Zhimin, Fu Huiying, Shou Qiyang

Abstract excerpt

BACKGROUND AND AIM: Diabetic nephropathy (DN) represents the primary contributor to end-stage renal disease worldwide, and its prevalence continues to grow, even with improvements in therapies aimed at lowering glucose levels. The progression of DN has been associated with lipid metabolism, yet the direct involvement of particular lipid species is still not fully understood. This study employs two-sample...

Topics

Mendelian Randomization Analysis
Humans
Diabetic Nephropathies
Risk Factors
Lipid Metabolism
Risk Assessment
Lipids
Biomarkers
Genome-Wide Association Study
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Single Nucleotide

Dyslipidemias

Source

Identifiers

PMID: 41549014
DOI: 10.1016/j.numecd.2025.104528

Genes

PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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