Article
HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis.
Gastroenterology - 1 Jan 1994
Mehal W Z, Lo Y M, Wordsworth B P, Neuberger J M, Hubscher S C, Fleming K A, Chapman R W
Abstract excerpt
BACKGROUND/AIMS: Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to esta...
Topics
- Amino Acid Sequence
- Antigens, Differentiation
- Autoimmune Diseases
- Base Sequence
- Cholangitis
- Chromosome Mapping
- Chronic Disease
- Colitis, Ulcerative
- Female
- Genotype
- HLA-DR4 Antigen
- Hepatitis
- Humans
- Leucine
- Male
- Middle Aged
- Molecular Sequence Data
- Oligonucleotide Probes