Article
HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis.
Gastroenterology - 1 Jan 1994
Mehal W Z, Lo Y M, Wordsworth B P, Neuberger J M, Hubscher S C, Fleming K A, Chapman R W
Abstract excerpt
BACKGROUND/AIMS: Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HLA associations with PSC and to assess the ability of HLA alleles to mark for disease progression....
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