Sex-Biased Regulation of Extracellular Matrix Genes in Chronic Obstructive Pulmonary Disease

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) often develops at an earlier age in women than in men, with worse respiratory symptoms despite lower smoking exposure. However, most preventive and therapeutic strategies ignore biological sex differences in COPD. Our goal was to better understand sex-specific gene regulatory processes in lung tissue and the molecular basis for sex differences in COPD onset and...

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