Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity.

doi:10.1038/s41467-024-50602-8

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Article

Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity.

Nature communications - 2 Aug 2024

Shabestary Kiyan, Klemm Cinzia, Carling Benedict, Marshall James, Savigny Juline, Storch Marko, Ledesma-Amaro Rodrigo

Abstract excerpt

In their natural environments, microorganisms mainly operate at suboptimal growth conditions with fluctuations in nutrient abundance. The resulting cellular adaptation is subject to conflicting tasks: growth or survival maximisation. Here, we study this adaptation by systematically measuring the impact of a nitrogen downshift to 24 nitrogen sources on cellular metabolism at the single-cell level. Saccharomyces...

Topics

Amino Acids
Nitrogen
Saccharomyces cerevisiae
Phenotype
Single-Cell Analysis
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 39095345
DOI: 10.1038/s41467-024-50602-8
PMCID: PMC11297284

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