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CDX2 and LEF‐1 expression in pilomatrical tumors and their utility in the diagnosis of pilomatrical carcinoma

25 Jan 2018

Abstract excerpt

BACKGROUND: The Wnt signaling pathway has been implicated in the pathogenesis of pilomatrical tumors. Lymphoid enhancer-binding factor 1 (LEF-1) is a downstream component of this pathway, and Caudal-related homeobox transcription factor 2 (CDX2) has been postulated to regulate it, but little is known about expression of these transcription factors in pilomatrical tumors. METHODS: Immunohistochemistry for CDX2,...

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PMID: 29369390
DOI: 10.1111/cup.13113

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