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Article

Functional analysis of FlbA-regulated transcription factor genes in Aspergillus niger using a multiplexed CRISPRoff system.

International journal of biological macromolecules - 1 Oct 2024

Chen Xiaoyi, Moran Torres Juan P, Tedjai S Vyanjan K, Lugones Luis G, Wösten Han A B

Abstract excerpt

FlbA of Aspergillus niger (indirectly) regulates 36 transcription factor (TF) genes. As a result, it promotes sporulation and represses vegetative growth, protein secretion and lysis. In this study, the functions of part of the FlbA-regulated TF genes were studied by using CRISPRoff. This system was recently introduced as an epigenetic tool for modulating gene expression in A. niger. A plasmid encompassing an...

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Aspergillus niger
CRISPR-Cas Systems
Fungal Proteins
Gene Expression Regulation, Fungal
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Transcription Factors

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PMID: 39089555
DOI: 10.1016/j.ijbiomac.2024.134326

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