Article
The pleiotropic phenotype of FlbA of Aspergillus niger is explained in part by the activity of seven of its downstream-regulated transcription factors.
Fungal genetics and biology : FG & B - 1 Jun 2024
Chen Xiaoyi, Moran Torres Juan P, Jan Vonk Peter, Damen J Mirjam A, Reiding Karli R, Dijksterhuis Jan, Lugones Luis G, Wösten Han A B
Abstract excerpt
Inactivation of flbA in Aspergillus niger results in thinner cell walls, increased cell lysis, abolished sporulation, and an increased secretome complexity. A total of 36 transcription factor (TF) genes are differentially expressed in ΔflbA. Here, seven of these genes (abaA, aslA, aslB, azf1, htfA, nosA, and srbA) were inactivated. Inactivation of each of these genes affected sporulation and, with the exception...
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