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Modelling glioblastoma resistance to temozolomide. A mathematical model to simulate cellular adaptation in vitro

31 Jul 2024

Abstract excerpt

Drug resistance is one of the biggest challenges in the fight against cancer. In particular, in the case of glioblastoma, the most lethal brain tumour, resistance to temozolomide (the standard of care drug for chemotherapy in this tumour) is one of the main reasons behind treatment failure and hence responsible for the poor prognosis of patients diagnosed with this disease. In this work, we combine the power of...

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PMID: 39089107
DOI: 10.1016/j.compbiomed.2024.108866

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