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Article

KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin.

Journal of pineal research - 1 Aug 2024

Yu Lijia, Chen Zhilin, Zhou Xiaolong, Teng Fei, Bai Qing-Ran, Li Lixi, Li Yunhong, Liu Ying, Zeng Qiyu, Wang Yong, Wang Meihua, Xu Yaling, Tang Xiaohui, Wang Xijin

Abstract excerpt

It is very crucial to investigate key molecules that are involved in myelination to gain an understanding of brain development and injury. We have reported for the first time that pathogenic variants p.R477H and p.P505S in KARS, which encodes lysyl-tRNA synthetase (LysRS), cause leukoencephalopathy with progressive cognitive impairment in humans. The role and action mechanisms of KARS in brain myelination during...

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PMID: 39087379
DOI: 10.1111/jpi.12998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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