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Article

SMC3 contributes to heart development by regulating super-enhancer associated genes.

Experimental & molecular medicine - 1 Aug 2024

Zhang Bowen, Zhu Yongchang, Zhang Zhen, Wu Feizhen, Ma Xiaojing, Sheng Wei, Dai Ranran, Guo Zhenglong, Yan Weili, Hao Lili, Huang Guoying, Ma Duan, Hao Bingtao, Ma Jing

Abstract excerpt

Abnormal cardiac development has been observed in individuals with Cornelia de Lange syndrome (CdLS) due to mutations in genes encoding members of the cohesin complex. However, the precise role of cohesin in heart development remains elusive. In this study, we aimed to elucidate the indispensable role of SMC3, a component of the cohesin complex, in cardiac development and its underlying mechanism. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

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Share to Enhancer Elements, Genetic

Share to Heart Defects, Congenital

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Source

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Identifiers

PMID: 39085358
DOI: 10.1038/s12276-024-01293-0
PMCID: PMC11372143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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