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Article

Pharmacogenomic Polygenic Model of Clopidogrel Predicts Recurrent Ischemic Events in Chinese Patients With Coronary Artery Disease.

Clinical therapeutics - 1 Aug 2024

Zhang Xinyi, Cai Yuchun, Zhou Pei, Nie Wenchang, Sun Haoning, Sun Yutong, Zhao Yuxuan, Han Congxiao, Cao Chengfu, Liu Jian, Nie Xiaoyan

Abstract excerpt

PURPOSE: Patients with coronary artery disease (CAD) need to take antiplatelet drugs regularly in order to prevent thrombosis; however, there is existing inter-individual variability in drug response. Pharmacogenomic studies indicate that drug response may also be influenced by genetic variants, and multiple genetic variants may work together. We assumed that patients carrying more risk alleles might have a worse...

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PMID: 39068057
DOI: 10.1016/j.clinthera.2024.06.019

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