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Article

The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing.

PloS one - 1 Jan 2024

Echeverría Omar, Angulo-Aguado Mariana, Vela Ricardo, Calderón-Ospina Carlos, Parra Katherine, Contreras Nora, Morel Adrien, Cabrera Rodrigo, Restrepo Carlos, Ramírez-Santana Carolina, Ortega-Recalde Oscar, Rojas-Quintana Manuel Eduardo, Murcia Luisa, Gaviria-Sabogal Cristian Camilo, Valero Nattaly, Fonseca-Mendoza Dora Janeth

Abstract excerpt

Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute coronary disease. Genetic factors influence interindividual variability in response. Some studies have explored the polygenic contributions in the drug response, generating pharmacogenomic risk scores (PgxPRS). Importantly, these factors are less explored in underrepresented populations, such as Latin-American countries....

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Identifiers

PMID: 38991024
DOI: 10.1371/journal.pone.0306445
PMCID: PMC11239111

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