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Article

Carcinogens induce genetic tandem duplications in Salmonella.

Mutation research - 1 Jan 2000

Pall M L, Hunter B J

Abstract excerpt

Extensive studies have shown that chemical carcinogenesis involves an initiation-promotion pattern. A gene amplification model of carcinogenesis predicts that initiation involves induction of a genetic tandem duplication. We use a system developed by Anderson and Roth to select for tandem duplication of the histidine operon of Salmonella typhimurium by selection for resistance to 3-amino-1,2,4-triazole. Evidence...

Topics

Amitrole
Azaserine
Carcinogens
Drug Resistance, Microbial
Heterozygote
Methyl Methanesulfonate
Methylnitronitrosoguanidine
Mutagenicity Tests
Mutagens
Mutation
Propiolactone
Salmonella typhimurium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transduction, Genetic

Triazoles

Ultraviolet Rays

Source

Identifiers

PMID: 3906387
DOI: 10.1016/0027-5107(85)90055-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3906387-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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