Quantitative relationship between mutagenic potency in the Ara test of Salmonella typhimurium and carcinogenic potency in rodents. A study of 11 direct-acting monofunctional alkylating agents.

Abstract excerpt

This work attempted to derive a quantitative relationship between mutagenicity and carcinogenicity by examining the association between mutagenic potency in the Ara test of Salmonella typhimurium and carcinogenic potency in rodents. Mutagenesis was monitored by selecting forward mutations to L-arabinose resistance. Lethality was measured at equivalent experimental conditions to those of mutant yield by using a...

Topics

• Alkylating Agents
• Animals
• Arabinose
• Carcinogenicity Tests
• Genetic Markers
• Mutagenicity Tests
• Mutation
• Neoplasms, Experimental
• Salmonella typhimurium
• Structure-Activity Relationship