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The combined inhibition of SLC1A3 and glutaminase in osimertinib-resistant EGFR mutant cells.

Biochimica et biophysica acta. General subjects - 1 Oct 2024

Ochi Nobuaki, Miyake Noriko, Takeyama Masami, Yamane Hiromichi, Fukazawa Takuya, Nagasaki Yasunari, Kawahara Tatsuyuki, Ichiyama Naruhiko, Kosaka Youko, Mimura Ayaka, Nakanishi Hidekazu, Hiraki Akio, Kiura Katsuyuki, Takigawa Nagio

Abstract excerpt

BACKGROUND: We investigated the unknown mechanisms of osimertinib-resistant EGFR-mutant lung cancer. METHODS: An osimertinib-resistant cell line (PC-9/OsmR2) was established through continuous exposure to osimertinib using an EGFR exon 19 deletion (19Del) lung adenocarcinoma cell line (PC-9). EGFR 19Del (M1), L858R/T790M/C797S (M6), and L858R/C797S (M8) expression vectors were introduced into Ba/F3 cells. A...

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PMID: 39059510
DOI: 10.1016/j.bbagen.2024.130675

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