Article
The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics.
Experimental cell research - 1 Mar 2023
Ochi Nobuaki, Takeyama Masami, Miyake Noriko, Fuchigami Maki, Yamane Hiromichi, Fukazawa Takuya, Nagasaki Yasunari, Kawahara Tatsuyuki, Nakanishi Hidekazu, Takigawa Nagio
Abstract excerpt
Most lung adenocarcinoma-associated EGFR tyrosine kinase mutations are either an exon 19 deletion (19Del) or L858R point mutation in exon 21. Although patients whose tumors contain either of these mutations exhibit increased sensitivity to tyrosine kinase inhibitors, progression-free and overall survival appear to be longer in patients with 19Del than in those with L858R. In mutant-transfected Ba/F3 cells, 19Del...
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