Article

Osimertinib induces paraptosis and TRIP13 confers resistance in glioblastoma cells

2022-07-11

Abstract excerpt

Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor that has been evaluated in glioblastoma (GBM) in pre-clinical and clinical trials. However, the precise mechanism whereby Osimertinib induces GBM cell death as well as the underlying resistance mechanism to Osimertinibremain unclear. Here we show that Osimertinib induced paraptosis in GBM cells as evidenced by the formatio...

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Literature Corpus work: bf152de1-b6cc-5363-ad1c-ee692d492e55
DOI: 10.21203/rs.3.rs-1771552/v1

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