Article
Impact of Low-Frequency Human Immunodeficiency Virus Type 1 Drug Resistance Mutations on Antiretroviral Therapy Outcomes.
The Journal of infectious diseases - 25 Jul 2024
Burdorf Rachel M, Zhou Shuntai, Amon Claire, Long Nathan, Hill Collin S, Adams Lily, Tegha Gerald, Chagomerana Maganizo B, Jumbe Allan, Maliwichi Madalitso, Wallie Shaphil, Li Yijia, Swanstrom Ronald, Hosseinipour Mina C
Abstract excerpt
BACKGROUND: The association between low-frequency human immunodeficiency virus type 1 (HIV-1) drug resistance mutations (DRMs) and treatment failure (TF) is controversial. We explore this association using next-generation sequencing (NGS) methods that accurately sample low-frequency DRMs. METHODS: We enrolled women with HIV-1 in Malawi who were either antiretroviral therapy (ART) naive (cohort A), had ART failure...
Topics
- Humans
- HIV-1
- Female
- HIV Infections
- Drug Resistance, Viral
- Adult
- Malawi
- Mutation
- Treatment Failure
- Anti-HIV Agents