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Article

Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals.

The Journal of antimicrobial chemotherapy - 1 Nov 2020

Chimukangara Benjamin, Giandhari Jennifer, Lessells Richard, Yende-Zuma Nonhlanhla, Sartorius Benn, Samuel Reshmi, Khanyile Khulekani S, Stray-Pedersen Babill, Moodley Pravi, Metzner Karin J, Padayatchi Nesri, Naidoo Kogieleum, De Oliveira Tulio

Abstract excerpt

OBJECTIVES: To determine the impact of pretreatment low-abundance HIV-1 drug-resistant variants (LA-DRVs) on virological failure (VF) among HIV-1/TB-co-infected individuals treated with NNRTI first-line ART. METHODS: We conducted a case-control study of 170 adults with HIV-1/TB co-infection. Cases had at least one viral load (VL) ≥1000 RNA copies/mL after ≥6 months on NNRTI-based ART, and controls had sustained...

Topics

Adult
Anti-HIV Agents
Case-Control Studies
Coinfection
Drug Resistance, Viral
HIV Infections
HIV-1
Humans
Mutation
Pharmaceutical Preparations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Treatment Failure

Viral Load

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Identifiers

PMID: 32772079
DOI: 10.1093/jac/dkaa343
PMCID: PMC7566390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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