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Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts

5 May 2022

Abstract excerpt

Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque trophoblast stem cells (TSC) that can be differentiated into early gestation syncytiotrophoblasts (ST) and extravillous trophoblasts (EVT). TSCs and STs, but not EVTs, were...

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PMID: 35513694
DOI: 10.1038/s41598-022-11275-9

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