Article
Failure of immune checkpoint inhibitors for microsatellite instability-positive pancreatic adenocarcinoma with atypical pattern of short tandem repeat mutation.
Immunotherapy - 1 Jan 2024
Babayan Anna, Ledin Evgeny, Lebedeva Alexandra, Kuznetsova Olesya, Kravchuk Daria, Grigoreva Tatiana, Belova Ekaterina, Kavun Alexandra, Mileyko Vladislav, Tryakin Alexey, Fedyanin Mikhail, Ivanov Maxim
Abstract excerpt
Microsatellite instability (MSI) is an important biomarker in cancer. While routine methods can detect MSI in certain tumor types, in other tumor types the results may be incorrect due to differences in the MSI loci pattern. Here, we report the case of a patient with pancreatic adenocarcinoma, with confirmed MSI by two independent next-generation sequencing tests, but not by routine methods, who had progression...
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