Article
Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype.
The American journal of pathology - 1 Oct 2024
Ogilvie Leslie M, Delfinis Luca J, Coyle-Asbil Bridget, Vudatha Vignesh, Alshamali Razan, Garlisi Bianca, Pereira Madison, Matuszewska Kathy, Garibotti Madison C, Gandhi Shivam, Brunt Keith R, Wood Geoffrey A, Trevino Jose G, Perry Christopher G R, Petrik Jim, Simpson Jeremy A
Abstract excerpt
Muscle atrophy and weakness are prevalent features of cancer. Although extensive research has characterized skeletal muscle wasting in cancer cachexia, limited studies have investigated how cardiac structure and function are affected by therapy-naive cancer. Herein, orthotopic, syngeneic models of epithelial ovarian cancer and pancreatic ductal adenocarcinoma, and a patient-derived pancreatic xenograft model,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.