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Article

Mutant NOTCH3ECD Triggers Defects in Mitochondrial Function and Mitophagy in CADASIL Cell Models.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Wang Wan, Gong Zhenping, Wang Yadan, Zhao Ying, Lu Yaru, Sun Ruihua, Zhang Haohan, Shang Junkui, Zhang Jiewen

Abstract excerpt

Background: Cerebral autosomal-dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL) is an inherited small-vessel disease that affects the white matter of the brain. Recent studies have confirmed that the deposition of NOTCH3ECD is the main pathological basis of CADASIL; however, whether different mutations present the same pathological characteristics remains to be further studied....

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Identifiers

PMID: 39031358
DOI: 10.3233/JAD-240273

Genes

NOTCH3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Mutant NOTCH3ECD Triggers Defects in Mitochondrial Function and Mitophagy in CADASIL Cell Models.PMID 39031358Read ↗

De novo Mutation Enables NOTCH3ECD Aggregation and Mitochondrial Dysfunction via Interactions with BAX and BCL-2.Semantic proximity Read ↗

Changes in the Morphology, Number, and Protein Levels of Plasma Exosomes in CADASIL Patients.Semantic proximity Read ↗

Ultrastructural Changes in Cerebral Capillary Pericytes in Aged Notch3 Mutant Transgenic MiceSemantic proximity Read ↗

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NOTCH3 Mutations in CADASIL Alter Lipid Metabolism: Insights from Patient Plasma and In Vitro Models.Semantic proximity Read ↗

A Novel NOTCH3 Frameshift Deletion and Mitochondrial Abnormalities in a Patient With CADASILSemantic proximity Read ↗

Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model.Semantic proximity Read ↗

NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease.Semantic proximity Read ↗

Asymptomatic cores and paracrystalline mitochondrial inclusions in CADASIL.Semantic proximity Read ↗

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family.Semantic proximity Read ↗

Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.Semantic proximity Read ↗

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