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Article

Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance.

Human genomics - 19 Jul 2024

Heczko Lucie, Liška Václav, Vyčítal Ondřej, Fiala Ondřej, Šůsová Simona, Hlaváč Viktor, Souček Pavel

Abstract excerpt

BACKGROUND: Colorectal cancer is still the second leading cause of cancer-related deaths and thus biomarkers allowing prediction of the resistance of patients to therapy and estimating their prognosis are needed. We designed a panel of 558 genes with pharmacogenomics records related to 5-fluorouracil resistance, genes important for sensitivity to other frequently used drugs, major oncodrivers, and actionable...

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Source

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Identifiers

PMID: 39030589
DOI: 10.1186/s40246-024-00644-2
PMCID: PMC11264515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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