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Article

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

19 Jul 2024

Abstract excerpt

Abstract Enteric glia have been recently recognized as key components of the colonic tumor microenvironment indicating their potential role in colorectal cancer pathogenesis. Although enteric glia modulate immune responses in other intestinal diseases, their interaction with the colorectal cancer immune cell compartment remains unclear. Through a combination of single-cell and bulk RNA-sequencing, both in murine...

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PMID: 39030280
DOI: 10.1038/s41467-024-50438-2

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