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Homologous Recombination Repair Deficiency and the Immune Response in Breast Cancer: A Literature Review

2 Jan 2020

Abstract excerpt

The success of cancer immunotherapy with immune checkpoint blockade (ICB) has demonstrated the importance of targeting a preexisting immune response in a broad spectrum of tumors. This is particularly novel and relevant for less immunogenic tumors, such as breast cancer (BC), where the efficacy of ICB was more evident in the triple-negative (TNBC) subtype, in earlier stages, and in association with chemotherapy....

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PMID: 31901781
DOI: 10.1016/j.tranon.2019.10.010

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