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Article

PEMPS: a phylogenetic software tool to model the evolution of metabolic pathways.

BMC bioinformatics - 18 Jul 2024

McCloskey Nicholas S, Mammedova Ayna, Liberles David A

Abstract excerpt

BACKGROUND: Metabolic pathways support the enzyme flux that converts input chemicals into energy and cellular building blocks. With a constant rate of input, steady-state flux is achieved when metabolite concentrations and reaction rates remain constant over time. Individual genes undergo mutation, while selection acts on higher level functions of the pathway, such as steady-state flux where applicable. Modeling...

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Identifiers

PMID: 39026162
DOI: 10.1186/s12859-024-05867-7
PMCID: PMC11264709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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