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Article

The role of cellular objectives and selective pressures in metabolic pathway evolution.

Current opinion in biotechnology - 1 Aug 2011

Nam Hojung, Conrad Tom M, Lewis Nathan E

Abstract excerpt

Evolution results from molecular-level changes in an organism, thereby producing novel phenotypes and, eventually novel species. However, changes in a single gene can lead to significant changes in biomolecular networks through the gain and loss of many molecular interactions. Thus, significant insights into microbial evolution have been gained through the analysis and comparison of reconstructed metabolic...

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Identifiers

PMID: 21481583
DOI: 10.1016/j.copbio.2011.03.006
PMCID: PMC3173765

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