Article
Mutation-selection balance and metabolic control theory.
Genetics - 1 Nov 1991
Clark A G
Abstract excerpt
The evolution of metabolic control is examined with models that unify approaches of classical quantitative genetics and metabolic control theory. The quantitative traits considered are the activities of enzymes embedded within metabolic pathways. In the models, polygenic mutation alters the enzyme activities (Vmax/Km) according to prescribed distributions, and the population evolves following classical haploid...
Topics
- Alleles
- Enzymes
- Metabolism
- Models, Theoretical
- Mutation
- Selection, Genetic