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Article

An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease.

NeuroImage - 15 Apr 2012

Fonteijn Hubert M, Modat Marc, Clarkson Matthew J, Barnes Josephine, Lehmann Manja, Hobbs Nicola Z, Scahill Rachael I, Tabrizi Sarah J, Ourselin Sebastien, Fox Nick C, Alexander Daniel C

Abstract excerpt

Understanding the progression of neurological diseases is vital for accurate and early diagnosis and treatment planning. We introduce a new characterization of disease progression, which describes the disease as a series of events, each comprising a significant change in patient state. We provide novel algorithms to learn the event ordering from heterogeneous measurements over a whole patient cohort and...

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Identifiers

PMID: 22281676
DOI: 10.1016/j.neuroimage.2012.01.062

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