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Article

Unexpected Voriconazole Overexposure in a CYP2C19 Rapid Metabolizer Due to Inflammation-Induced Phenoconversion: A Short Communication.

Therapeutic drug monitoring - 1 Oct 2026

Drevin Guillaume, Picard Nicolas, Briet Marie, Abbara Chadi

Abstract excerpt

BACKGROUND: Voriconazole exhibits substantial interindividual pharmacokinetic variability, largely driven by cytochrome P450 enzymes, particularly CYP2C19 and CYP3A4. Although pharmacogenetics plays a key role in predicting voriconazole exposure, systemic inflammation may transiently suppress CYP activity, leading to inflammation-induced phenoconversion. This mechanism can cause clinically relevant drug...

Read the complete abstract on PubMed

Topics

Female
Humans
Antifungal Agents
Cytochrome P-450 CYP2C19
Drug Monitoring
Genotype
Inflammation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Voriconazole

Aged

Source

Identifiers

PMID: 42300127
DOI: 10.1097/FTD.0000000000001493

Genes

CYP2C19
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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