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Article

Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants.

Nature chemical biology - 1 Sept 2024

Neupane Krishna, Narayan Abhishek, Sen Mojumdar Supratik, Adhikari Gaurav, Garen Craig R, Woodside Michael T

Abstract excerpt

Many neurodegenerative diseases feature misfolded proteins that propagate via templated conversion of natively folded molecules. However, crucial questions about how such prion-like conversion occurs and what drives it remain unsolved, partly because technical challenges have prevented direct observation of conversion for any protein. We observed prion-like conversion in single molecules of superoxide dismutase-1...

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PMID: 39009686
DOI: 10.1038/s41589-024-01672-8

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