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Article

Intercellular Prion-Like Conversion and Transmission of Cu/Zn Superoxide Dismutase (SOD1) in Cell Culture.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Grad Leslie I, Pokrishevsky Edward, Cashman Neil R

Abstract excerpt

The prion hypothesis has extended to the fatal motor neuron disease, amyotrophic lateral sclerosis (ALS), as a means to explain the spatiotemporal spread of pathology from one or more focal points through the neuroaxis. About 20% of inheritable cases of ALS are due to mutation in the gene encoding the Cu/Zn superoxide dismutase (SOD1), causing the protein to misfold and form neurotoxic aggregates. Mutant SOD1 has...

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Identifiers

PMID: 28861801
DOI: 10.1007/978-1-4939-7244-9_24

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SOD1

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