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Construction and validation of a senescence-related gene signature for early prediction and treatment of osteoarthritis based on bioinformatics analysis

30 Dec 2024

Abstract excerpt

The aim of this study is to screen key target genes of osteoarthritis associated with aging and to preliminarily explore the associated immune infiltration cells and potential drugs. Differentially expressed senescence-related genes (DESRGs) selected from Cellular senescence-related genes (SRGs) and differentially expressed genes (DEGs) were analyzed using Gene Ontology enrichment, Kyoto Encyclopedia of Genes and...

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Computational Drug Discovery Methods
Cytokine Signaling Pathways and Interactions
Osteoarthritis Treatment and Mechanisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39738612
DOI: 10.1038/s41598-024-83268-9

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