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Article

Effect of CO binding to P450 BM3 F393 mutants on electron density distribution in the heme cofactor.

Journal of inorganic biochemistry - 1 Oct 2024

Schelvis Johannes P M, Chen Zhucheng, Messina Marisa A, Catalano Jaclyn

Abstract excerpt

Resonance Raman spectroscopy has been performed on a set of cytochrome P450 BM3 heme domains in which mutation of the highly conserved Phe393 induces significant variation in heme iron reduction potential. In previous work [Chen, Z., Ost, T.W.B., and Schelvis, J.P.M. (2004) Biochemistry 43, 1798-1808], a correlation between heme vinyl conformation and the heme iron reduction potential indicated a steric control...

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Identifiers

PMID: 39002177
DOI: 10.1016/j.jinorgbio.2024.112660

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