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Article

Protein biomarkers for response to XPO1 inhibition in haematologic malignancies

1 Feb 2023

Abstract excerpt

XPO1 (Exportin-1) is the nuclear export protein responsible for the normal shuttling of several proteins and RNA species between the nucleocytoplasmic compartment of eukaryotic cells. XPO1 recognizes the nuclear export signal (NES) of its cargo proteins to facilitate its export. Alterations of nuclear export have been shown to play a role in oncogenesis in several types of solid tumour and haematologic cancers....

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PMID: 36722323
DOI: 10.1111/jcmm.17667

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