Article
Allelic frequencies of polymorphism c.521T>C (rs4149056) favor preemptive SLCO1B1 genotyping in Armenia.
Drug metabolism and personalized therapy - 1 Sept 2024
Németh Stefan, Kriegshäuser Gernot, Hayrapetyan Hasmik, Oberkanins Christian, Sarkisian Tamara
Abstract excerpt
OBJECTIVES: Statins represent an important pharmacological factor for the prevention of cardiovascular diseases but may also cause severe cases of myotoxicity. Numerous studies have described the association of the SLCO1B1 gene variant c.521C with statin-induced myopathy across different populations. This study aimed at evaluating the usefulness of preemptive SLCO1B1 genotyping in Armenia. METHODS: A total of 202...
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